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Cabrini University President Donald B. Taylor, PhD, with a graduating student

Research, Publications, and Presentations

Donald B. Taylor, PhD

President Taylor’s research interests have included the biochemical, cellular and molecular mechanisms of blood platelet aggregation, blood clot formation, and cell-cell interactions, to the design, synthesis, and characterization of novel pharmaceutical compounds for the use in the study of hemostasis and thrombosis.

His research interests in higher education have included problem-based learning, effective partnerships in science education at the K–16 level, and educational technologies.


SELECTED BIBLIOGRAPHY: 

  • Gartner, T. K. and D. B. Taylor. “The amino acid sequence gly-ala-pro-leu appears to be a fibrinogen binding site in the platelet integrin, glycoprotein IIb.” Thrombosis Research 60, 291-309, 1990.
  • Gartner, T.K., Loudon, R. and D. B. Taylor. “The peptides APLHK, EHIPA and GAPL are hydropathically equivalent peptide mimics of a fibrinogen binding domain of glycoprotein IIb/IIIa.” Biochem. Biophys. Res. Comm.  180, 1446-1452, 1991.
  • Gartner, T. K. and D. B. Taylor.  “The peptide glu-his-ile-pro-ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin.” Proc. Society Experimental Biol. Medicine 198, 649-655, 1991.
  • Taylor, D. B. and T. K. Gartner. “A peptide corresponding to GPIIb 300-312, a presumptive fibrinogen gamma-chain binding site on the platelet integrin GPIIb/IIIa, inhibits the adhesion of platelets to at least four adhesive ligands.” J. Biol. Chem. 267: 11729-11733, 1992.
  • Gartner, T. K., Amrani, D. L., Derrick, J. M., Kirschbaum, N. E., Matsueda, G. R. and Taylor, D. B.  “Characterization of adhesion of “resting” and stimulated platelets to fibrinogen and its fragments.” Thrombosis Research 71: 47-60, 1993.
  • Taylor, D. B., Derrick, J. M. and T. K. Gartner. “Antibodies to GPIIb alpha (300-3120 inhibit Fg binding, clot retraction and platelet adhesion to multiple ligands.” P.S.E.B.M, 205: 1-9, 1994.
  • Gartner, T. K., Taylor, D. B. and Derrick, J. M. “Complementary peptides that interfere with platelet aggregation and adhesion.” ImmunoMethods. 5: 148-157, 1994.
  • Gartner, T. K., Amrani, D. L., Derrick, J. M., Kirschbaum, N. E., Matsueda, G. R. and Taylor, D. B.  “Characterization of adhesion of resting and stimulated platelets to fibrinogen.”Ann NY Acad Sci 714:303-305, 1994.
  • Wang, X., Lessman, C. A., Taylor, D. B. and Gartner, T. K. “Fibronectin peptides GRGDSP and DRVPHSRNSIT and fibronectin receptor peptide DLYYLMDL arrest gastrulation of Rana pipiens.” Experentia,31:1097-1102,1995.
  • Wang, X., Coons, L.B., Taylor, D.B, Stevens, S.E., Gartner, T.K. “Variabilin, a novel RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis.” J. Biol. Chem. 271: 17785-17790, 1996.
  • Taylor DB, Dhutia B, Styrsky J. “Characterization of the effects of ATP and related nucleotides on clot retraction.” MOLECULAR BIOLOGY OF THE CELL Volume: 7 Pages: 1643-1643 Suppl. S, 1996.
  • Derrick, J. M., Taylor, D. B., Loudon, R. and Gartner, T. K. “The peptide LSARLAF causes platelet secretion and aggregation by directly activating the integrin alphaIIbalpha3.” Biochemical Journal, 325, 309-313, 1997.
  • Wysocki JM, Dhutia B, Styrsky J, and DB Taylor. “Adenosine nucleotides can modulate integrin alpha IIb beta 3 recognition of fibrinogen (FG), fibrin and non-FG ligands.” FASEB JOURNAL   Volume: 11 Issue: 9 Pages: A1094-A1094, Suppl. S, 1997.
  • Taylor DB, Smith RA, Gartner TK, et al. “Adenosine nucleotides can modulate integrin alpha IIb beta 3 and alpha v beta 3 recognition of fibrin (ogen) [FG].” MOLECULAR BIOLOGY OF THE CELL Volume: 8 Pages: 1678-1678, Suppl. S, 1997.
  • Derrick JM, Taylor DB, and Gartner TK. “Platelet agglutination driven by the peptide LSARLAF is not dependent on staurosporin sensitive tyrosine phosphorylation.” THROMBOSIS AND HAEMOSTASIS Pages: P1084-P1084, Suppl. S, 1997.
  • Taylor DB, Dhutia B, Styrsky J, et al. “Characterization of the effects of ATP and related nucleotides on clot retraction and platelet adhesion to immobilized substrates.” THROMBOSIS AND HAEMOSTASIS Pages: P1955-P1955, Suppl. S, 1997.
  • Gartner TK, Poncz M, Taylor DB, et al. “The peptide LSARLAF activates platelets in an alpha IIbb3 dependent manner.” BLOOD Volume: 92 Issue: 10 Pages: 28A-28A Part 1 Suppl. 1, 1998.
  • Taylor DB, Derrick JM, Gartner TK, et al. “Peptides which directly activate integrin alpha IIb beta 3 or the thrombin receptor (TR) induce platelet-mediated retraction of fibrin (FBN) clots.” MOLECULAR BIOLOGY OF THE CELL Volume: 9 Pages: 417A-417A Suppl. S, 1998.
  • Barbeau GM, Taylor DB, Carlson ML. “Simulated platelet receptor fibrinogen peptide interactions.” BIOPHYSICAL JOURNAL Volume: 74 Issue: 2 Pages: A280-A280, Part 2, 1998.
  • Badenhorst AJ, Taylor DB, Carlson ML. “Disintegrin structure and platelet receptor peptide interactions.” BIOPHYSICAL JOURNAL Volume: 74 Issue: 2 Pages: A280-A280, Part 2, 1998.
  • Fornek JL, Budovec J, Khan M, and DB Taylor. “A comparative study of the cell adhesion of human platelets to fibronectin (FN) and pronectin F (PNF).” The FASEB JOURNAL Volume: 13 Issue: 7 Pages: A1361-A1361, Suppl. S, 1999.
  • Ong JF, Cicero JA, Gartner TK, and DB Taylor. “Prediction of erythropoietin and erythropoietin receptor interactions by computer assisted searches for complementary peptide sequences.” The FASEB JOURNAL Volume: 13 Issue: 7 Pages: A1403-A1403, Suppl. S., 1999.
  • Barbeau BM, Taylor DB, and Carlson ML. “Fibrinogen platelet receptor interaction studied by homology modeling.” BIOPHYSICAL JOURNAL Volume: 76 Issue: 1Pages: A201-A201, Part 2, 1999.
  • Perak, RV, RA Smith, and DB Taylor. “8-Azido ATP inhibits platelet and endothelial cell attachment to thrombospondin.” The FASEB Journal Vol. 13, #7, A1361, 1999.
  • Carlson ML, Barbeau GM, and Taylor DB. “Homology modeling of fibrinogen (FG), platelet receptor interaction.” THROMBOSIS AND HAEMOSTASIS Pages: 160-160, Suppl. S, 1999.
  • Taylor DB, Fornek JL, Perak RV, et al. “Characterization of the receptor specificity of 8-azido ATP (8AA).” MOLECULAR BIOLOGY OF THE CELL Volume: 10 Pages: 344A-344A, Suppl. S, 1999.
  • Abraham B, Carroll HR, Muller EM, Derrick, JM, TK Gartner, and DB Taylor. “The peptide LSARLAF induces platelet-mediated retraction of fibrin (FBN) clots in an alpha IIb beta 3 dependent manner.” FASEB JOURNAL Volume: 13 Issue: 7 Pages: A1361-A1361, Suppl. S, 1999.
  • Thiyagarajan V, Roman A, Smith RA, and DB Taylor. “Effects of adenosine nucleotides on integrin recognition of immobilized collagens (CG).” FASEB JOURNAL Volume: 13 Issue: 7 Pages: A1361-A1361, Suppl. S, 1999.
  • Perak, RV, Gasiorowski, JZ, Gartner, TK and DB Taylor. “Cytochalasin D regulation of alpha integrins is not due to a direct effect of CD on the receptor.” The FASEB Journal Vol. 14, #8 A1546, 2000.
  • Taylor, DB, Marin, HM, Thompson, D, Perak, RV, Gasiorowski, JZ, Piech, R, Derrick, JM, and TK Gartner. “The peptide LSARLAF activates integrin alphaIIbbeta3 liposomes and elicits homotypic binding of these vesicles.” The FASEB Journal Vol. 15, #5 (Part II) A866, 2001.
  • Taylor DB, Derrick JM, Carroll HR, et al. “Design, synthesis and characterization of an integrin receptor activating peptide.” MOLECULAR BIOLOGY OF THE CELL Volume: 12 Pages: 321A-322A, Suppl. S, 2001.
  • Taylor, DB, Derrick, JM, Cho, MJ, Loudon, RG, Carroll, HR, Edgar, C, Marin, HM, Petrikas, JJ, Raval, DG and TK Gartner. “The peptide LSARLAF directly induces a conformation change in the platelet integrin alphaIIbeta3.” MOLECULAR BIOLOGY OF THE CELL Vol. 13S, 348a, 2002.
  • Taylor, DB, Derrick, JM, Cho, MJ, Loudon, RG, Carroll, HR, Edgar, C, Marin, HM, Petrikas, JJ, Raval, DG and TK Gartner. “The peptide LSARLAF is a novel strong agonist for human blood platelets.” The FASEB Journal Vol. 16, #5 (Part II) A899, 2002.
  • RL Peksa, VJ Siomos, BD Sward, P Koliou, NJ Kucera, HP Moy, JM Derrick, MJ Cho, CW Jackson, EL Ferroni, EM Winkler, TK Gartner and DB Taylor. “Evidence that the mechanism of LSARLAF-induced alphaIIbbeta3-dependent outside-in signal transduction in platelets is not dependent on dimerization of alphaIIbbeta3 complexes.” The FASEB Journal Vol. 17, #5 (Part II) A1364, 2003.
  • Hughes KE, Kucera NJ, Koliou P, Ferroni, EL and DB Taylor. “Analysis of the binding of peptide fragments corresponding to the putative platelet recognition sequences of fibrinogen and the integrin alpha IIbbeta3 by isothermal titration calorimetry.” The FASEB JOURNAL Vol. 17, #5 (Part II) A1364, 2003.
  • Taylor, DB, SA Kelly, ML Ogilvie, DA Walz and TK Gartner. “Characterization of Thrombospondin and Fibrinogen Interactions.” The FASEB Journal Vol. 18, #5 (Part II) A1364, 2004.
  • B Collander, C. Ondracek, DB Taylor and A Wilson. “Potentiation of growth factor signaling by integrin agonist peptide LSARLAF during in vitro generation of osteoclasts.”  The FASEB Journal Vol. 19, #4 (Part I) A820, 2005.
  • Taylor, DB. “Integrating Technology in the Teaching of the Undergraduate Molecular Cell Biology Curriculum.” MOLECULAR BIOLOGY OF THE CELL Vol. 17S, 1953a, 2006.
  • Taylor, DB. “Promoting Interdisciplinary Connections in the Undergraduate Biochemistry and Molecular Biology Curriculum.” The FASEB Journal Vol. 21, #4 (Part II) A5355, 2007.
  • Taylor, DB, EM Kolich, JC Mickus, G Ketterling. “Problem-Based Learning Pedagogy and the Science Education Training of Teachers” Submitted 11/2007, and abstract accepted for AAAS 2008 Annual Meeting, 2/17/2008.
  • Taylor, DB, EM Kolich, JC Mickus, G Ketterling. “Science Education Training of Pre-Service Teachers: Using Problem-Based Learning as a Pedagogy of Engagement” AAC&U and PKAL STEM meeting abstract accepted for presentation March, 2011.
  • Taylor, DB. “Why is college still a good investment?” Daily Herald, December 12, 2011.
  • Niu, H, Xu, Z, Li, D, Zhang, L, Wang, K, DB Taylor, TK Gartner, and Liu, J. “Peptide LSARLAF induces integrin BETA-3 dependent outside-in signaling in platelets” Thrombosis Research, 2012 Aug;130(2):203-9.

SELECTED HONORS/AWARDS and ACTIVITIES

  • Selected to be a member of the Council of Independent Colleges [CIC] and Lilly yearlong program “Presidential Vocation and Institutional Mission: A seminar for Prospective College and University Presidents and Their Spouses” (2012-13)
  •  Selected to be a participant of the AALI/CIC Seminar on Leadership for the 21st Century for Chief Academic Officers (2010)
  • Selected to be a member of the Institute for New CAOs at ACE: Center for Effective Leadership (2008)
  • Recipient of the Presidential Award for Leadership at annual Benedictine University Employee Honors Event (2005)
  • Selected for Faculty Merit Award (2004-05 & 1997-98)
  • Department of Biology recognized for Student’s Choice Award for Customer Service at annual Benedictine University Employee Honors Event; Served as Department Chair (2003)
  • Recognition for Outstanding Teaching and Service by a Science Teacher: the Class of 2000 Undergraduate Students (2000)
  • Recognition for Outstanding Biology Faculty Member by BU’s Tri-B Iota Pi Chapter (1999-2000)
  • Recipient of theWilliam M. Scholl Endowed Research Professorship in Health Sciences; Benedictine University (1997-2000).
  • Member of faculty team that was the Recipient of Presidential Award for Innovation for Design and Implementation of Natural Sciences Laboratory Sequence at annual Benedictine University Employee Honors Event (1998)
  • Submitted abstract selected to be presented at the International Congress on Thrombosis and Haemostasis Meetings (1989, 91, 95, 97, 99, 2001, 03).
  • Chosen to be a presenter of five papers at the “New World Science for the Next Millennium” Joint Congress of Biochemistry and Molecular Biology Meetings, Western Hemispheres (5/99).
  • Chosen to be a presenter at the Intl Congress of Biochemistry and Molecular Biology Meetings (8/97, meeting cancelled due to SARS outbreak).
  • Chosen to be a presenter at the 6th International Congress on Cell Biology Conference (12/96).
  • BACHEM PHARMACEUTICALS and PENINSULA LABS (BIOTECHNOLOGY COMPANIES) consider at least six synthetic peptides developed during the past twenty years  by colleagues at the Univ. of Memphis and myself are of sufficient interest to the scientific community that they have been made available commercially at different times as laboratory reagents (1996-2007 Product Guides).
  • Nominated for NSF Presidential Faculty Fellow Program, 1994 and 1995.
  • Nominated for NSF Young Investigator Award Program, 1994.
  • Invited Speaker for the Mini-Symposium on Platelet Adhesion at the XIVth Congress of the International Society on Thrombosis and Haemostasis (July 5, 1993).
  • Chosen to be a presenter at the International Hematology meetings in Aug. 1992.
  • Recipientof a Research Fellowship from the Van Vleet Memorial Cancer Foundation (9/90-8/92).
  • One of four MSU graduate students honored for excellence in research and academic achievement at annual President’s banquet (1990)
  • First place in the second annual Graduate Research Forum (Life and Health Sciences Division), MSU (1990)
  • Second place in the second annual Graduate Research Forum (Life and Health Sciences Division), MSU (1989)
  • Outstanding research presentation at Mid-South Biology Colloquium (March, 1989)
  • Invited keynote speaker at Tennessee Academy of Sciences Annual UG Research Symposium (April, 1988)
  • Outstanding student research paper at Mid-South Biology Colloquium (March, 1988)

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